PUBLICATION

Bio-integrated Electronics Lab.

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Rapidly Customizable, Scalable 3D-Printed Wireless Optogenetic Probes for Versatile Applications in Neuroscience

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작성자 최고관리자 작성일 24-09-02 13:36

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Author
Juhyun Lee, Kyle E. Parker, Chinatsu Kawakami, Jenny R. Kim, Raza Qazi, Junwoo Yea,Shun Zhang, ... , Kyung-In Jang, Jordan G. McCall,*and Jae-Woong Jeong
Journal
Advanced functional materials
Vol
30(46)
Page
2004285

Optogenetics is an advanced neuroscience technique that enables the dissec-tion of neural circuitry with high spatiotemporal precision. Recent advancesin materials and microfabrication techniques have enabled minimally inva-sive and biocompatible optical neural probes, thereby facilitating in vivooptogenetic research. However, conventional fabrication techniques rely oncleanroom facilities, which are not easily accessible and are expensive to use,making the overall manufacturing process inconvenient and costly. Moreover,the inherent time-consuming nature of current fabrication procedures impedethe rapid customization of neural probes in between in vivo studies. Here, anew technique stemming from 3D printing technology for the low-cost, massproduction of rapidly customizable optogenetic neural probes is introduced.The 3D printing production process, on-the-fly design versatility, and biocom-patibility of 3D printed optogenetic probes as well as their functional capabili-ties for wireless in vivo optogenetics is detailed. Successful in vivo studies with3D printed devices highlight the reliability of this easily accessible and flexiblemanufacturing approach that, with advances in printing technology, can fore-shadow its widespread applications in low-cost bioelectronics in the future.